Acute Liver Failure to Fluoxetine Therapy

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Muhammad Tahir, MD

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Published: 19 July 2018 | Article Type :

Abstract

Fluoxetine is a commonly prescribed antidepressant. The hepatic failure reported secondary to this particular drug is very rare i.e. 0.5% of the patients who are taking this drug for long term therapy. The routine monitoring is not advised for someone on maintenance therapy. The exact mechanism is still unknown. We reported a case of hepatic failure in a 35 year old patient who was started on this drug for her persistent depression. The presenting complaint was jaundice with a cholestatic manifestations. The workup was unremarkable, other than liver enzymes dysfunction (ALT 1129 U/L, AST 1892 U/L). The hepatitis panel and imaging was negative. Ultimately biopsy was done which showed portal, periportal and lobular hepatitis. The working diagnosis of Drug-induced liver injury was made and patient showed improvement in her condition in 2-4 weeks. The patient was also followed at outpatient clinic and the liver enzymes were normalized.

Keywords: drug-induced liver injury, hepatic failure, SSRI.

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Muhammad Tahir, MD. (2018-07-19). "Acute Liver Failure to Fluoxetine Therapy." *Volume 1*, 1, 14-15